Dear All It is really giving me a hard to get this techniques if you want to run the update panel in sharepoint 2013 webpart then you need to initialize the script manage by code   protected override void OnInit(EventArgs e)         {             base.OnInit(e);             InitializeControl();             // Register the ScriptManager             ScriptManager scriptManager = ScriptManager.GetCurrent(this.Page);             if (scriptManager == null)             {                 scriptManager = new ScriptManager();                 scriptManager.ID = "ScriptManager1";                 scriptManager.EnablePartialRendering = true;       ...